THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION

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Abstract

Abstract. The outcome of hepatitis C virus (HCV) infection depends on the immune response caused by the host genetic factors. Cytokines are key mediators of inflammation and development of specific immunity, which is responsible for the elimination of HCV. It has been found that the polymorphisms in several cytokine genes play role in human susceptibility to HCV infection, determine its differences in response to HCV and treatment-induced HCV clearance. This review summarizes the results of studies on the single-nucleotide polymorphisms of cytokine genes that complete our knowledge of the pathogenesis of HCV infection.

About the authors

N. A. Arsentieva

ФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург

Author for correspondence.
Email: arsentieva_n.a@bk.ru

научный сотрудник лаборатории молекулярной иммунологии и сероэпидемиологии

197101, Санкт-Петербург, ул. Мира, 14

Russian Federation

A. V. Semenov

ФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург

Email: arsentieva_n.a@bk.ru
Russian Federation

Areg A. Totolian

ФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург

Email: arsentieva_n.a@bk.ru
Russian Federation

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