Email this article COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
- Authors: Toptygina A.P.1, Alioshkin V.A.1
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Affiliations:
- G.N. Gabrichevsky Research Institut for Epidemiology and Microbilogy, Moscow
- Issue: Vol 3, No 4 (2013)
- Pages: 359-364
- Section: SHORT COMMUNICATIONS
- URL: https://iimmun.ru/iimm/article/view/148
- DOI: https://doi.org/10.15789/2220-7619-2013-4-359-364
- ID: 148
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Abstract
Abstract. Twenty healthy children were vaccinated, and then in a 5 years they were revaccinated with Priorix (measles, mumps, rubella vaccine), according to the national immunization calendar. The aim of the study was to observe and compare the shaping and maintenance of immunological memory. Specific IgM, IgA, IgG antibodies in serum, and their subclasses as well as antibodies avidity were tested by ELISA. It was demonstrated that IgM, IgG, and IgA antibodies shaped primary immune response to Priorix. Booster-effect was found in IgG and IgA antibodies in response to revaccination. Low avidity of antibodies in primary immune response changed to the high avidity (60–70%) antibodies of memory response to measles and rubella, and remained low for antimumps antibodies. IgG3 subclass was predominant, and IgG1 and IgG4 subclasses were involved in primary immune response. At the stage of immunological memory IgG1 was predominanted and IgG3 and IgG4 became minor.
Keywords
About the authors
A. P. Toptygina
G.N. Gabrichevsky Research Institut for Epidemiology and Microbilogy, Moscow
Author for correspondence.
Email: toptyginaanna@rambler.ru
PhD (Medicine), Leading Researcher, Laboratory of Cytokine
25212, Russian Federation, Moscow, Admiral Makarov str., 10
Russian FederationV. A. Alioshkin
G.N. Gabrichevsky Research Institut for Epidemiology and Microbilogy, Moscow
Email: toptyginaanna@rambler.ru
PhD, MD (Biology), Director Russian Federation
References
- Топтыгина А.П., Пухальский А.Л., Мамаева Т.А., Алешкин В.А. Спектр субклассов противокоревых иммуноглобулинов G у лиц, перенесших корь // Бюлл. экспер. биол. — 2004. — Т. 137, № 3. — С. 293–295. Toptygina A.P., Pukhal`skiy A.L., Mamaeva T.A., Aleshkin V.A. Spektr subklassov protivokorevykh immunoglobulinov G u lits, perenesshikh kor` [Measles virus specific IgG subclass in early and late infections]. Byullyuten` eksperimental`noy biologii — Bull. Exp. Biol., 2004, vol. 137, no. 3, pp. 293–295.
- Топтыгина А.П., Семикина Е.Л., Копыльцова Е.А., Алешкин В.А. Возрастные особенности формирования гуморального звена иммунного ответа у детей // Медицинская иммунология. — 2012. — Т. 14, № 4–5. — С. 289–294. Toptygina A.P., Semikina E.L., Kopyl`tsova E.A., Aleshkin V.A. Vozrastnye osobennosti formirovaniya gumoral`nogo zvena immunnogo otveta u detey [Age-dependent features of evolving humoral immunity in children]. Meditsinskaya immunologiya – Medical Immunology, 2012, vol. 14, no. 4–5, pp. 289–294.
- Ярилин А.А. Иммунология. — М.: ГЭОТАР-Медиа, 2010. — С. 752. Yarilin A.A. Immunologiya [Immunology]. Мoscow, GEOTAR-Media, 2010, 752 p.
- Centers for Disease Control and Prevention. Multistate measles outbreak associated with an international youth sporting event — Pennsylvania, Michigan and Texas. MMWR Morb. Mortal. Wkly. Rep, 2008, vol. 57, pp. 169–173.
- Hickman C.J., Hyde T.B., Sowers S.B., Mercader S., McGrew M., Williams N.J., Beeler J.A., Audet S., Kiehl B., Nandy R., Tamin A., Bellini W.J. Laboratory characterization of measles virus infection in previously vaccinated and unvaccinated individuals. J. Infect. Dis., 2011, vol. 204, supl. 1, pp. 549–558.
- Orenstein W.A., Strebel P.M., Papania M., Sutter R.W., Bellini W.J., Cochi S.L. Measles eradication: is it in our future? Am. J. Public Health, 2000, vol. 90, pp. 1521–1525.
- Toptygina A.P., Pukhalsky A.L., Alioshkin V.A. IgG subclass profile of antimeasles response in vaccinated children and adults with measles history. Clin. Diag. Lab. Immunol., 2005, vol. 12, no. 7, pp. 845–847.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).