Email this article Parthenolide: suggested drug for COVID-19
- Authors: Nemati M.1, Danesh Pouya F.1, Roshani Asl E.1, Rami Y.1
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Affiliations:
- Urmia University of Medical Sciences
- Issue: Vol 10, No 4 (2020)
- Pages: 789-791
- Section: SHORT COMMUNICATIONS
- URL: https://iimmun.ru/iimm/article/view/1509
- DOI: https://doi.org/10.15789/2220-7619-PSD-1509
- ID: 1509
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the 2019 novel coronavirus (2019-nCoV) that causes acute respiratory distress syndrome (ARDS) which is the main reason for patients mortality. One of the effective treatments to reduce the effects of this virus is parthenolide (PN). Parthenolide is a sesquiterpene lactone found in medicinal plants. It can inhibit several pro-inflammatory signaling pathways, in particular the ATPase activity of NLRP3. Based on its ability to suppress inflammatory signal transduction and elevated level of serum IL-1β (a surrogate marker for NLRP3 activation) in COVID-19 patients, we suggest that PN could be potentiallyeffective for the treatment of COVID-19.
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About the authors
M. Nemati
Urmia University of Medical Sciences
Email: mohadese.nemati@yahoo.com
ORCID iD: 0000-0002-4262-1636
Department of Biochemistry, School of Medicine.
Urmia Russian Federation
F. Danesh Pouya
Urmia University of Medical Sciences
Email: f_daneshpouya@hotmail.com
ORCID iD: 0000-0002-2636-9856
Department of Biochemistry, School of Medicine.
Urmia Iran, Islamic Republic of
E. Roshani Asl
Urmia University of Medical Sciences
Email: eli.roshani@yahoo.com
ORCID iD: 0000-0002-9783-5156
Department of Biochemistry, School of Medicine.
Urmia Iran, Islamic Republic of
Y. Rami
Urmia University of Medical Sciences
Author for correspondence.
Email: rasmiy@umsu.ac.ir
ORCID iD: 0000-0003-1506-1909
Yousef Rasmi - Department of Biochemistry, School of Medicine, Urmia University MS; Cellular and Molecular Research Center, Urmia UMS.
Urmia, Phone: +989143174740, Fax: +984432780801
Iran, Islamic Republic ofReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).