THE ROLE OF CYTOLOGICAL AND VIROLOGICAL STUDIES IN SECONDARY PREVENTION OF CERVICAL CANCER

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Abstract. This article is devoted to the role of cytological and virological screening in the secondary prevention of cervical cancer. Five hundred and fifty two cases of carcinoma in situ (of cervical cancer) and 1248 cases of invasive cervical cancer over a period of 15 years were analyzed. This period has separated into three stages: I — 1998–2002, II — 2003–2007, III — 2008–2012 years. Cervical cancer morbidity in Karelia is reported to increase tripled from 10.5 to 30.5 causes per 100 thousand women population. The excess incidence has identified among young women in reproductive age including 
an age group < 30 year. It has been noticed that the detection rate of carcinoma in situ was statistically significant increased from 24.34±9.2% in 1998–2002 to 62.8±20.9% in 2008–2012 years. There are three different level regional groups of early cervical cancer detection (0–I–II stage) in the Republic of Karelia. Despite of the fact, that the cervical cancer is increas-ing significantly, there are a good results of its early diagnostics, thanking to the cytological and virological screening in Karelia.

About the authors

E. V. Bahidze

Federal state-financed institution «N.N. Petrov Research Institute of Oncology» of Russian Ministry of Health, St. Petersburg

Email: pkovchur@mail.ru
PhD, MD (Medicine), Leading Researcher, Department of Oncogynecology Russian Federation

P. I. Kovchur

Federal state-financed educational institution of high professional education «Petrozavodsk State University», Petrozavodsk

Author for correspondence.
Email: pkovchur@mail.ru

PhD (Medicine), Associate Professor, Department of Radiation Diagnosics, Therapy, Oncology, Tuberculosis and Urology

185910, Russian Federation, Petrozavodsk, Lenina pr., 33

 

Russian Federation

A. V. Yastrebova

Federal state-financed educational institution of high professional education «Petrozavodsk State University», Petrozavodsk

Email: pkovchur@mail.ru
Assistant Professor, Department of Radiation Diagnosics, Therapy, Oncology, Tuberculosis and Urology Russian Federation

References

  1. Ашрафян Л.А., Киселев В.И. Современные возможности профилактики и ранней диагностики предрака и рака репродуктивных органов // Акушерство и гинекология. — 2009. — № 4. — С. 24–29. Ashrafyan L.A., Kiselev V.I. Sovremennye vozmozhnosti profilaktiki i ranney diagnostiki predraka i raka reproduktivnykh organov [Modern possibilities of prevention and early diagnosis of precancer and cancer of the reproductive organs]. Akusherstvo i ginekologiya — Obstetrics and Gynecology, 2009, no. 4, pp. 24–29.
  2. Бахидзе Е.В., Аршавская И.Л. Роль вируса папилломы человека в диагностике, мониторинге и прогнозе рака шейки матки // Сибирский онкологический журнал. — 2012. — № 3 (51). — С. 34–40. Bakhidze E.V., Arshavskaya I.L. Rol` virusa papillomy cheloveka v diagnostike, monitoringe i prognoze raka sheyki matki [The role of human papillomavirus in the diagnosis, monitoring and prognosis of cervical cancer]. Sibirskiy onkologicheskiy zhurnal — Siberian Journal of Oncology, 2012, no. 3 (51), pp. 34–40.
  3. Бахлаев И.Е., Ковчур П.И., Михетько А.А., Курмышкина О.В., Нильва С.Е. Рак шейки матки шейки матки в Карелии // Вестник РОНЦ им. Н.Н. Блохина РАМН. — 2011. — Т. 22, № 1. — С. 22–28. Bakhlaev I.E., Kovchur P.I., Mikhet`ko A.A., Kurmyshkina O.V., Nil`va S.E. Rak sheyki matki v Karelii [Cervical cancer in Karelia]. Vestnik RONTS im. N.N. Blokhina RAMN — Bulletin of the RCRC of N.N. Blokhin., 2011, vol. 22, no. 1, pp. 22–28.
  4. Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2009 г. // Вестник РОНЦ им. Н.Н. Блохина РАМН. — 2011. — Т. 22, № 3. — С. 54–92. Davydov M.I., Aksel` E.M. Statistika zlokachestvennykh novoobrazovaniy v Rossii i stranakh SNG v 2009 g. [Statistics of malignancies in Russia and the CIS in 2009]. Vestnik RONTS im. N.N. Blokhina RAMN — Bulletin of the RCRC of N.N. Blokhin, 2011, vol. 22, no. 3, pp. 54–92.
  5. Козаченко В.П. Современные возможности предупреждения рака шейки матки // Опухоли женской репродуктивной системы. — 2007. — № 3. — С. 47–48. Kozachenko V.P. Sovremennye vozmozhnosti preduprezhdeniya raka sheyki matki [Modern possibilities of preventing cervical cancer]. Opukholi zhenskoy reproduktivnoy sistemy — Tumors of the Female Reproductive System, 2007, no. 3, pp. 47–48.
  6. Короленкова Л.И. Ассоциированные с инфекцией вируса папилломы человека маркеры возникновения и прогрессии цервикальных интраэпителиальных неоплазий: от научных разработок к клинической практике // Опухоли женской репродуктивной системы. — 2010. — № 4. — С. 64–70. Korolenkova L.I. Assotsiirovannye s infektsiey virusa papillomy cheloveka markery vozniknoveniya i progressii tservikal`nykh intraepitelial`nykh neoplaziy: ot nauchnykh razrabotok k klinicheskoy praktike [Associated with human papilloma virus infection markers and progression of cervical intraepithelial neoplasia: from scientific research to clinical practice]. Opukholi zhenskoy reproduktivnoy sistemy — Tumors of the Female Reproductive System, 2010, no. 4. pp. 64–70.
  7. Лялина Л.В., Касаткин Е.В. Папилломавирусная инфекция и рак: современное состояние и перспективы развития интегрированой системы надзора и профилактики в Россиии // Папилломавирусная инфекция и рак. Интегированная система надзора и профилактики: материалы II симп. с междунар. участием. Санкт-Петербург, Россия, 7–9 июня 2011 г. — СПб.: НИИЭМ им. Пастера, 2011. — С. 7–10. Lyalina L.V., Kasatkin E.V. Papillomavirusnaya infektsiya i rak: sovremennoe sostoyanie i perspektivy razvitiya integrirovanoy sistemy nadzora i profilaktiki v Rossiii [Human papillomavirus infection and cancer: current status and prospects of integrating the surveillance and prevention in Russia] Papillomavirusnaya infektsiya i rak. Integirovannaya sistema nadzora i profilaktiki: materialy II simpozium s mezhdunarodnym uchastiem. Sankt-Peterburg, Rossiya, 7–9 iyunya 2011 goda [HPV infection and cancer. An integrated system of surveillance and prevention: Proceedings of the II Symposium with international participation. St. Petersburg, Russia, June 7–9, 2011]. St. Petersburg: Pasteur Institute, 2011, pp. 7–10.
  8. Мерабишвили В.М., Лалианци Э.И., Субботина О.Ю. Рак шейки матки: заболеваемость, смертность (популяционное исследование) // Вопросы онкологии. — 2012. — Т. 58, № 1. — С. 41–44. Merabishvili V.M., Laliantsi E.I., Subbotina O.Yu. Rak sheyki matki: zabolevaemost`, smertnost` (populyatsionnoe issledovanie) [Cervical cancer: incidence, mortality (population survey)]. Voprosy onkologii – Problems of Oncology, 2012, vol. 58, no. 1, pp. 41–44.
  9. Новик В.И. Скрининг рака шейки матки // Практическая онкология. — 2010. — Т. 11, № 2. — С. 66–73. Novik V.I. Skrining raka sheyki matki [Cervical cancer screening]. Prakticheskaya onkologiya — Practical Oncology, 2010, vol. 11, no. 2, pp. 66–73.
  10. Чиссов В.И. Злокачественные новообразования в России в 2010 г. (заболеваемость и смертность) / Под ред. В.И. Чиссова, В.В. Старинского, Г.В.Петровой. — М.: ФГУ МНИОИ им. П.А. Герцена Росмедтехнологий, 2012. — 260 с. Chissov V.I. Zlokachestvennye novoobrazovaniya v Rossii v 2010 godu (zabolevaemost` i smertnost`) (Pod red. V.I. Chissova, V.V. Starinskogo, G.V. Petrovoy) [Malignancies in Russia in 2010 (morbidity and mortality) (Ed. V.I. Chissov, V.V. Starinskiy, G.V. Petrova)]. Moscow: FSI «MNIOI named after P.A. Gertsen Rusmedtechnologies», 2012, p. 260.
  11. American College of Obstetricians and Gynаecologists. COG Practice Bulletin No. 99: Management of abnormal cervical cytology and histology. Obstet. Gynaecol., 2008, vol. 112, no. 6, pp. 1419–1444.
  12. Arbyn M., Sasieni P., Meijer C.J., Clavel C., Koliopoulos G., Dillner J. Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses. Vaccine, 2006, vol. 24, suppl. 3, pp. 78–89.
  13. Bosch F.X., Lorinz A., Munoz N., Meijer C.J., Shah K.V. The causal relation between human papillomavirus and cervical cancer. J. Clin. Pathol., 2002, vol. 55, no. 4, pp. 244–265.
  14. Cancer incidence in Five Continents. Vol. IX. Eds. M.P. Curado, B. Edwards, Shin H.R., Storm H., Ferlay J., Heanue M., Boyle P. IARC Scient. Publ. 160, Lyon: IARC. 2008, 960 p.
  15. Cancer in Finland 2002 and 2003. Cancer Society of Finland. Helsinki, 2005, no. 66, pp. 11–57.
  16. Dunne E.F., Datta S.D., Markowitz E.L. A review of prophylactic human papillomavirus vaccines: recommendations and monitoring in the US. Cancer, 2008, vol. 113, pp. 2995–3003.
  17. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 2010, vol. 127, no. 12, pp. 2893–917.
  18. Hoyer H., Scheungraber C., Kuehne-Heid R., Teller K., Greinke C., Leistritz S., Ludwig B., Durst M., Schneider A. Cumulative 5-year diagnoses of CIN2, CIN3 or cervical cancer after concurrent high-risk HPV and cytology testing in a primary screening setting. Int. J. Cancer, 2005, vol. 116, pp. 136–143.
  19. Lazarczyk M., Cassonet P., Pons C., Jacob Y., Favre M. The EVER proteins as natural barrier against papillomavirus: a new insight into the pathogenesis of human papillomavirus infections. Microbiol. Mol. Biol. Rev., 2009, vol. 73, pp. 348–370.
  20. Meijer C.J.L.M., Berkhof J., Castle P.E., Hesselink A., Franco E.L., Ronco G., Arbyn M., Bosch F.X., Cuzick J., Dillner J., Heideman D.A.M., Snijders P.J.F. Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older. Int. J. Cancer, 2009, vol. 124, no. 3, pp. 516–520.
  21. Steen R. Cervical cancer prevention strategies in Norway — screening and vaccination. Human papillomavirus infection and cancer. Integration surveillance system and prevention: II symposium with international participation. St. Peterburg, 2011, pp. 10–11.

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