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Пол пациента влияет на ответ систем организма и клинический исход при COVID-19

https://doi.org/10.15789/2220-7619-GRR-1664

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Аннотация

Коронавирус тяжелого острого респираторного синдрома (SARS-CoV-2) является седьмым представителем семейства коронавирусов (CoV), патогенным для человека, и возбудителем коронавирусного инфекционного заболевания (COVID-19), достигшего к настоящему времени масштаба глобальной пандемии. Было показано, что на ранней стадии тяжелых случаев заболевания секретируется значительный объем цитокинов. Это может стать важным фактором быстрого прогрессирования заболевания. Системное воспаление указывает на запущенную стадию острого заболевания, которая характеризуется полиорганной недостаточностью и повышенным уровнем ключевых воспалительных маркеров. Ранее проведенные исследования продемонстрировали гендерные различия в уровне заболеваемости и смертности от COVID-19. В данном обзоре мы исследовали гендерные различия в системных эффектах COVID-19 и обнаружили, что подобные различия наиболее выражены в дыхательной, сердечно-сосудистой системах, желудочно-кишечном тракте, печени и почках. На основании регистрации худшего исхода COVID-19 у мужчин высказано предположение о возможном влиянии женских половых гормонов на течение болезни. Женские половые гормоны, особенно эстроген и, возможно, прогестерон, могут оказывать системное и местное действие на различные типы клеток, а также регулировать локальные уровни ангиотензинпревращающего фермента 2 (ACE2). Установлено, что вирус SARS-CoV-2 проникает в клетку через ACE2. Мы полагаем, что рассмотренные в настоящем обзоре гендерные различия позволят улучшить ведение пациентов с COVID-19.

Об авторах

M. Хаксари
Керманский университет медицинских наук
Иран

Доктор наук, профессор физиологии, Исследовательский центр нейронаук, Институт нейрофармакологии, Керманский университет медицинских наук; Исследовательский центр эндокринологии и метаболизма, Институт фундаментальных и клинических физиологических наук, медицинский факультет, Керманский университет медицинских наук.

Керман.



Н. Сабэт
Керманский университет медицинских наук
Иран

Кандидат наук (физиология), Исследовательский центр тропических и инфекционных заболеваний, Керманский университет медицинских наук; Исследовательский центр эндокринологии и метаболизма, Институт фундаментальных и клинических физиологических наук, медицинский факультет, Керманский университет медицинских наук; старший ассистент, кафедра физиологии и фармакологии медицинского факультета им. А. Афзалипюра, Керманский университет медицинских наук.

Керман.



З. Солтани
Керманский университет медицинских наук
Иран

Солтани Захра - доктор наук, профессор физиологии, Исследовательский центр эндокринологии и метаболизма, Институт фундаментальных и клинических физиологических наук, медицинский факультет, Керманский университет медицинских наук; Исследовательский центр тропических и инфекционных заболеваний, Керманский университет медицинских наук; кафедра физиологии и фармакологии, медицинский факультет им. А. Афзалипюра, Керманский университет медицинских наук.

Керман.

Тел./факс: +98 3433257581.



Х. Башири
Керманский университет медицинских наук; Сирджанский университет медицинских наук
Иран

Доктор наук, профессор фармакологии, Научно-исследовательский центр нейронаук, Институт нейрофармакологии, Керманский университет медицинских наук; медицинский факультет Сирджанского университета медицинских наук.

Керман; Сирджан.



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Хаксари M., Сабэт Н., Солтани З., Башири Х. Пол пациента влияет на ответ систем организма и клинический исход при COVID-19. Инфекция и иммунитет. 2021;11(6):1020-1036. https://doi.org/10.15789/2220-7619-GRR-1664

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Khaksari M., Sabet N., Soltani Z., Bashiri H. Gender-related response of body systems in COVID-19 affects outcome. Russian Journal of Infection and Immunity. 2021;11(6):1020-1036. https://doi.org/10.15789/2220-7619-GRR-1664

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