Инфекция и иммунитет

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The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients

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Background. Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. Oxygenation disturbances in sepsis patients may cause increase lactate levels which is proportional to the severity of the inflammation, followed by decrease in albumin levels. Combination of these two parameters is expected to be predictor of mortality in patients with sepsis. The aim of this study is to investigate the profile of lactate, albumin, and lactate/albumin ratio as mortality predictors in patient with sepsis.

Methods. This prospective cohort study was conducted in the ICU of dr. Saiful Anwar Hospital Malang from January to May 2019. Subjects were 82 patients with sepsis (SOFA score >2). Lactate and albumin levels were measured on the first day of hospitalization. Lactate levels were examined by colorimetric method, albumin were examined by BCG method. The instrument used was Cobas 501. Comparation was carried out using the T-Test/Mann-Whitney test. Prediction of mortality risk was done using relative risk (RR) determination.

Results. Significant difference was observed in albumin levels between sepsis patients who survived and who died (p = 0.045). No significant differences were observed in lactate levels and lactate/albumin ratio between sepsis patients who survived and who died (p = 0.211, 0.119, respectively). Relative risks were 3.034 for lactate, 3.667 for albumin, and 4.400 for lactate/albumin ratio. Lactate levels >4.0 mmol/L have an RR value of 3.034 in predicting mortality in septic patients.

Conclusions. In patients with sepsis, lactate/albumin ratio is the best variable in predicting mortality, followed by albumin and lactate value. Further study that implements repeated measurement of lactate and albumin 6 and 12 hour is required to better predict the mortality of sepsis patients.

Об авторе

Andrea Aprilia
Brawijaya University

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. . Инфекция и иммунитет. 2021;.

For citation:

Aprilia A. The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients. Russian Journal of Infection and Immunity. 2021;.

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ISSN 2220-7619 (Print)
ISSN 2313-7398 (Online)