The profile of lactate, albumin, and lactate/albumin ratio as predictors of mortality in sepsis patients

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Abstract

Background. Oxygenation disturbances in sepsis patients may cause lactate levels increase which is proportional to the severity of the inflammation, followed by decrease in albumin levels. Combination of these two parameters is expected to be predictor of mortality in patients with sepsis. The aim of this study is to investigate the profile of lactate, albumin, and lactate/albumin ratio as mortality predictors in patient with sepsis. Methods. This prospective cohort study was conducted in the ICU of dr. Saiful Anwar Hospital, Malang, from January to May 2019. Subjects were 82 patients with sepsis (SOFA score > 2). Lactate and albumin levels were measured on the first day of hospitalization. Lactate levels were examined by colorimetric method, albumin was examined by BCG method. The instrument used was Cobas 501. Comparation was carried out using the T-Test/Mann–Whitney test. Prediction of mortality risk was done using relative risk (RR) determination. Results. Significant difference was observed in albumin levels between sepsis patients who survived and who died (p = 0.045). No significant differences were observed in lactate levels and lactate/albumin ratio between sepsis patients who survived and who died (p = 0.211, 0.119, respectively). Relative risks were 3.034 for lactate, 3.667 for albumin, and 4.400 for lactate/albumin ratio. Conclusion. In patients with sepsis, albumin level is the best variable in predicting mortality, followed by lactate/albumin ratio and lactate value. Further study that implements repeated measurement of lactate and albumin in 6 and 12 hours is required to better predict the mortality of sepsis patients.

About the authors

A. Iskandar

Universitas Brawijaya; Dr. Saiful Anwar General Hospital

Email: fake@neicon.ru

Clinical Pathologist, Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya; Dr. Saiful Anwar General Hospital.

Malang.

Indonesia

M. I. Vincentia

Airlangga University

Email: fake@neicon.ru

Clinical Pathologist, Faculty of Medicine, Airlangga University.

Surabaya.

Indonesia

W. Jaya

Universitas Brawijaya; Dr. Saiful Anwar General Hospital

Email: fake@neicon.ru

Anaesthesiologist, Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Brawijaya; Dr. Saiful Anwar General Hospital.

Malang.

Indonesia

A. Aryati

Airlangga University; Dr. Soetomo General Hospital

Email: fake@neicon.ru

PhD, MD (Medicine), Professor of Clinical Pathology, Department of Clinical Pathology, Faculty of Medicine, Airlangga University; Dr. Soetomo General Hospital.

Surabaya.

Indonesia

A. Pramadhani

Universitas Brawijaya

Email: fake@neicon.ru

Student, Faculty of Medicine, Universitas Brawijaya.

Malang.

Indonesia

A. Aprilia

Universitas Brawijaya

Author for correspondence.
Email: andreaaprilia134@gmail.com
ORCID iD: 0000-0002-9732-9878

Andrea Aprilia - Clinical Pathologist, Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya; Dr. Saiful Anwar General Hospital.

65145, East Java, Malang, Lowokwaru, Veteran str.

Phone: +62 (8577) 400-90-60

Indonesia

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Copyright (c) 2021 Iskandar A., Vincentia M.I., Jaya W., Aryati A., Pramadhani A., Aprilia A.

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