Email this article SEROLOGICAL DIAGNOSIS OF MODERN CHOLERA USING LIPOSOMAL ENTEROTOXIC DIAGNOSTICUM IN COMPLEMENT FIXATION TEST
- Authors: Savelyeva I.V.1, Bezsmertnyj V.E.2, Savelyev V.N.1, Fedorov Y.M.2, Ivanova C.M.2, Ivannikov V.V.2
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Affiliations:
- The Federal Government Public Health Institution “Stavropol Institute for Plague Control of the Rospotrebnadzor”, Stavropol
- The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow
- Issue: Vol 3, No 3 (2013)
- Pages: 285-288
- Section: SHORT COMMUNICATIONS
- URL: https://iimmun.ru/iimm/article/view/177
- DOI: https://doi.org/10.15789/2220-7619-2013-3-285-288
- ID: 177
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Abstract
Abstract. The possibility of serological diagnosis of cholera using cholera enterotoxic diagnostics kit in complement fixation test to detect anti-enterotoxic antibodies in sera of patients with cholera caused by hybrid variants of the El Tor biovar has been demonstrated. In patients with mild course of cholera anti-enterotoxic antibodies were detected in titres 1:50 and 1:200 in paired sera obtained on the 7th and 14th days of disease, respectively (fourfold titre increase). In patients with the course of medium severity 32-fold titre increase was recorded from the titre 1:100 in serum obtained on the fifth day of disease till the titre 1:3200 — on the twelfth day of disease. Antibodies titers reached 1:1600 and 1:800 were revealed in two medium course patients (adult and infant of 10 months) on the sixth day of disease.
About the authors
I. V. Savelyeva
The Federal Government Public Health Institution “Stavropol Institute for Plague Control of the Rospotrebnadzor”, Stavropol
Author for correspondence.
Email: snipchi@mail.stv.ru
PhD (Medicine), Senior Research Associate, Laboratory of media for cultivation of microorganisms of I–IV groups of pathogenicity
355035, Russian Federation, Stavropol, Sovetskaya Street, 13–15Russian Federation
V. E. Bezsmertnyj
The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow
Email: snipchi@mail.stv.ru
PhD (Medicine), Director Russian Federation
V. N. Savelyev
The Federal Government Public Health Institution “Stavropol Institute for Plague Control of the Rospotrebnadzor”, Stavropol
Email: snipchi@mail.stv.ru
PhD, MD (Medicine), Senior Research Associate, Chief, Laboratory for Diagnosis of Cholera and Other Intestinal Infections Russian Federation
Yu. M. Fedorov
The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow
Email: snipchi@mail.stv.ru
PhD, MD (Medicine), Professor, Deputy Director Russian Federation
C. M. Ivanova
The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow
Email: snipchi@mail.stv.ru
Deputy Director Russian Federation
V. V. Ivannikov
The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow
Email: snipchi@mail.stv.ru
Chief, Bacteriological Laboratory Russian Federation
References
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