Results of implementation of viral hepatitis B elimination program in the North-West Russia

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Abstract

Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.

About the authors

L. V. Lyalina

St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: lyalinas@pasteurorg.ru
ORCID iD: 0000-0001-9921-3505

Lyudmila V. Lyalina,  PhD, MD (Medicine), Professor, Head of the Laboratory of Epidemiology of Infectious and Non-infectious Diseases; Professor of Department of Epidemiology, Parasitology and Desinfectology

197101, St. Petersburg, Mira str., 14

Phone: +7 921 584-63-85 (mobile) 

Russian Federation

E. V. Esaulenko

St. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical University

Email: eve-gpmu@mail.ru
ORCID iD: 0000-0003-3669-1993

PhD, MD (Medicine), Professor, Head of the Viral Hepatitis Laboratory; Head of the Department of Adult Infectious Diseases and Epidemiology

St. Petersburg

Russian Federation

E. V. Khorkova

Leningrad Regional Center for the Prevention and Control of AIDS and Infectious Diseases

Email: Khorkovae@yandex.ru
ORCID iD: 0000-0002-6550-1872

Head Physician Deputy 

St. Petersburg

Russian Federation

K. E. Novak

St. Petersburg State Pediatric Medical University

Email: kseniya.novak@mail.ru
ORCID iD: 0000-0001-9633-4328

PhD (Medicine), Associate Professor, Department of Adult Infectious Diseases and Epidemiology 

St. Petersburg

Russian Federation

Y. V. Ostankova

St. Petersburg Pasteur Institute

Email: shenna1@yandex.ru
ORCID iD: 0000-0003-2270-8897

PhD (Biology), Senior Researcher, Laboratory of Molecular Immunology 

St. Petersburg

Russian Federation

E. N. Serikova

St. Petersburg Pasteur Institute

Email: elena.donetsk.serikova@mail.ru
ORCID iD: 0000-0002-0547-3945

Researcher, Laboratory of Virology and Immunology of HIV Infection 

St. Petersburg

Russian Federation

D. V. Vasilyev

Polyclinic No. 48

Email: justgreen@mail.ru

Epidemiologist 

St. Petersburg

Russian Federation

E. S. Gorziy

St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. Mechnikov

Email: egorziy@yandex.ru
ORCID iD: 0000-0003-4195-679X

Investigator, Laboratory of Epidemiology of Infectious and Non-infectious Diseases 

St. Petersburg

Russian Federation

M. J. Butskaya

St. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical University

Email: butskaya.masha@yandex.ru

PhD Student, Department of Infectious Diseases of Adults and Epidemiology; Junior Researcher, Viral Hepatitis Laboratory 

St. Petersburg

Russian Federation

I. V. Kritskaya

Rospotrebnadzor Office for St. Petersburg

Email: kritskaya.i.v@gmail.com
ORCID iD: 0000-0002-6103-7013

Deputy Head of the Epidemiological Surveillance Department 

St. Petersburg

Russian Federation

L. V. Buts

Rospotrebnadzor Office for Leningrad Region

Email: lidabuts@mail.ru
ORCID iD: 0000-0002-2631-0256

Head of the Epidemiological Surveillance Department 

St. Petersburg

Russian Federation

E. V. Grebenkina

Rospotrebnadzor Office for Novgorod Region

Email: homochk@mail.ru

Deputy Head of the Epidemiological Surveillance Department 

Velikiy Novgorod

Russian Federation

E. V. Baydakova

Rospotrebnadzor Office for Arkhangelsk Region; Northern State Medical University of the Ministry of Health of Russian Federation

Email: elenabaydakova@yandex.ru

Chief Special Expert, Epidemiological Surveillance Department; Assistant Professor, Hygiene and Medicine Ecology Department 

Arkhangelsk

Russian Federation

N. A. Smirnova

Rospotrebnadzor Office for Vologda Region

Email: sirnnik78@mail.ru

Deputy Head of the Epidemiological Surveillance Department 

Vologda

Russian Federation

M. A. Krasnopyorova

Rospotrebnadzor Office for Kaliningrad Region

Email: epidotdel@39.rospotrebnadzor.ru

Chief Special Expert, Department of Epidemiological Surveillance and Sanitary Protection 

Kaliningrad

Russian Federation

N. S. Koltsov

Rospotrebnadzor Office for Murmansk Region

Email: kolcov_ns@murmanpotrebnadzor.ru

Head of the Epidemiological Surveillance Department 

Murmansk

Russian Federation

L. M. Kotovich

Rospotrebnadzor Office for the Republic of Karelia

Email: glavepid@yandex.ru

Acting Head  

Petrozavodsk

Russian Federation

E. L. Kalinina

Rospotrebnadzor Office for Pskov Region

Email: epid@60.rospotrebnadzor.ru

Head of the Epidemiological Surveillance Department 

Pskov

Russian Federation

R. R. Galimov

Rospotrebnadzor Office for Komi Republic

Email: galimov@gsenkomi.ru

Head of the Epidemiological Surveillance Department 

Syktyvkar

Russian Federation

N. V. Kirkhar

Rospotrebnadzor Office for Nenets Autonomous Okrug

Email: turpnnao@mail.ru

Head 

Naryan-Mar

Russian Federation

E. A. Cherepanova

Federal Center of Hygiene and Epidemiology

Email: cherepanovaea@fcgic.ru

Deputy Head of the Epidemiological Surveillance Department 

Moscow

Russian Federation

Areg A. Totolian

St. Petersburg Pasteur Institute

Email: totolian@spbraaci.ru
ORCID iD: 0000-0003-4571-8799

RAS Full Member, PhD, MD (Medicine), Professor, Head of the Laboratory of Molecular Immunology; Director 

St. Petersburg

Russian Federation

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Copyright (c) 2021 Lyalina L.V., Esaulenko E.V., Khorkova E.V., Novak K.E., Ostankova Y.V., Serikova E.N., Vasilyev D.V., Gorziy E.S., Butskaya M.J., Kritskaya I.V., Buts L.V., Grebenkina E.V., Baydakova E.V., Smirnova N.A., Krasnopyorova M.A., Koltsov N.S., Kotovich L.M., Kalinina E.L., Galimov R.R., Kirkhar N.V., Cherepanova E.A., Totolian A.A.

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