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НАРУЖНАЯ МЕМБРАНА ПАТОГЕННЫХ ПРЕДСТАВИТЕЛЕЙ РОДА LEPTOSPIRA

https://doi.org/10.15789/2220-7619-2011-1-29-42

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Аннотация

Резюме. Патогенные лептоспиры способны поражать широкий спектр хозяев, и длительно сохраняются в окружающей среде. Наружная мембрана — компонент клетки, участвующий во взаимодействии микроорганизма со средой обитания. В настоящее время описан ряд белков, представленных в наружной мембране лептоспир и отвечающих за колонизацию организма хозяина, защиту от воздействия иммунной системы, поступление веществ в клетку и ряд других процессов. Наружная мембрана содержит белки и молекулы липополисахарида, обладающие цитотоксическим эффектом. Показано, что регуляция белкового состава мембран зависит от ряда факторов окружающей среды, таких как температура, осмолярность, наличие в среде тех или иных веществ. Как липополисахарид, так и белковые молекулы наружной мембраны обладают антигенными свойствами. Препараты таких соединений могут использоваться в практических целях, как компоненты лептоспирозных вакцин и диагностикумов. Настоящий обзор посвящен вопросам структурной организации наружной мембраны лептоспир, разнообразия входящих в ее состав молекул и регуляции их синтеза, а также перспективам практического применения компонентов наружной мембраны в сфере диагностики и профилактики лептоспирозной инфекции.

Об авторе

А. Н. Ваганова
ФГУН «Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера» Роспотребнадзора, Санкт-Петербург
Россия

научный сотрудник лаборатории зооантропонозных инфекций

197101, Санкт-Петербург, ул. Мира, 14



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Для цитирования:


Ваганова А.Н. НАРУЖНАЯ МЕМБРАНА ПАТОГЕННЫХ ПРЕДСТАВИТЕЛЕЙ РОДА LEPTOSPIRA. Инфекция и иммунитет. 2011;1(1):29-42. https://doi.org/10.15789/2220-7619-2011-1-29-42

For citation:


Vaganova A.N. THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS. Russian Journal of Infection and Immunity. 2011;1(1):29-42. (In Russ.) https://doi.org/10.15789/2220-7619-2011-1-29-42

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