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СТРАТЕГИИ ПРОГРАММИРОВАННОЙ КЛЕТОЧНОЙ ГИБЕЛИ У ПРОКАРИОТ

https://doi.org/10.15789/2220-7619-2015-1-15-26

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Аннотация

Программированная гибель клеток (ПГК) была впервые изучена в эукариотических организмах. Эта система также функционирует в процессе развития прокариот. Система ПГК у микроорганизмов активируется широким спектром сигналов в ответ на стрессы, связанные с неблагоприятными условиями окружающей среды или воздействием антибактериальных средств. Результаты многочисленных исследований, проведенных в последнее десятилетие, позволяют рассматривать систему ПГК у прокариот как средство эволюционного сохранения вида. Эти результаты существенно расширили представления о роли ПГК у микроорганизмов и открыли ряд важных направлений исследований, морфологических и молекулярно-генетических подходов к изучению стратегий смерти ради выживания у бактериальных популяций. Цель обзора: обобщение сведений о морфологических и молекулярно-генетических признаках ПГК у прокариот, являющихся реальными проявлениями механизмов этого феномена. 

Об авторах

Б. Г. Андрюков
690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.
Россия

д.м.н., ведущий научный сотрудник лаборатории молекулярной эпидемиологии и микробиологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия;



Л. М. Сомова
690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.
Россия

д.м.н., профессор, директор ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия; 



Н. Ф. Тимченко
690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.
Россия

д.м.н., профессор, ведущий научный сотрудник лаборатории молекулярной эпидемиологии
и микробиологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия. 



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Для цитирования:


Андрюков Б.Г., Сомова Л.М., Тимченко Н.Ф. СТРАТЕГИИ ПРОГРАММИРОВАННОЙ КЛЕТОЧНОЙ ГИБЕЛИ У ПРОКАРИОТ. Инфекция и иммунитет. 2015;5(1):15-26. https://doi.org/10.15789/2220-7619-2015-1-15-26

For citation:


Andrukov B.G., Somova L.M., Timchenko N.F. STRATEGY OF PROGRAMMED CELL DEATH IN PROKARYOTES. Russian Journal of Infection and Immunity. 2015;5(1):15-26. (In Russ.) https://doi.org/10.15789/2220-7619-2015-1-15-26

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