INDICES OF IMMUNE RESPONSE IN PATIENTS OF FALCIPARUM MALARIA IN REPUBLIC OF GUINEA

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Abstract

Malaria in the Republic of Guinea is the main cause of morbidity and lethality. It takes the first place in number of all visits in medical service (30–40%) and is the main cause of hospital death. One records annually more than 8 millions malaria cases, and about 60 000 children deaths. Results of study of immune response changing on different disease phases in treatment of autochthon population and immune status of Europeans are presented. It was shown that immunity status (cellular and humoral) in population of Guinea (an endemic country on falciparum malaria) differs from one in Europeans living in tropics. During light forms of malaria one records an increase of T-lymphocyte and IgG number, whereas in grave cases one observed the acute decrease of these indices. The essential increase of B-lymphocyte number does not depends from gravity of disease and from malaria treatment. It was established that appearance of LSA1-41 antibodies was in a more degree in adult patients than in children. The positive correlation between IgM and IgG was established in adult patients as in children.

About the authors

M. Y. Boiro

Pasteur Institute of Guinea

Email: fake@neicon.ru

PhD (Biology), Professor, General Director,

Kindia

Guinea

S. Boumbali

Pasteur Institute of Guinea

Email: fake@neicon.ru

PhD (Biology), Professor, Director of Doctor’s School,

Kindia

Guinea

O. K. Konstantinov

Pasteur Institute of Guinea

Author for correspondence.
Email: olegkonst@mail.ru

PhD (Biology), Researcher,

Kindia, ВР146

Guinea

S. Kalivogui

Pasteur Institute of Guinea

Email: fake@neicon.ru

PhD (Biology), Vice-Director,

Kindia

Guinea

M. Koulibali

International Research Center of Tropical Infections

Email: fake@neicon.ru

PhD (Biology), Director,

Nzerekore

Guinea

A. S. Bah

Pasteur Institute of Guinea

Email: fake@neicon.ru

Researcher,

Kindia

Guinea

References

  1. Гвинея. Справочник. Москва: Наука, 1980. 270 c. [Gvinea. Spavochnik. [Guinea. Guide]. Moscow: Nauka, 1980, 270 p.
  2. Bouharoun-Tayoun H., Oeuvray C., Lunel F., Druilhe P. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J. Exp. Med., 1995, vol. 182, no. 2, pp. 409–418.
  3. Bruneel F. Paludisme grave. Anésthésie-réanimation, 2009, 36-984-B-10, doi: 10.1016/S0246-0289(09)50990-5
  4. Camara B., Kantambadouno J.B., Martin-Blondel G., Berry A., Alvarez M., Benoit-Vical F., Delmont J., Bouchaud O., Marchou B. Splénomégalie palustre hyperimmune : à propos de trois cas cliniques et revue de la littérature. Méd. Mal. Infect., 2009, vol. 39, no. 1, pp. 29–35, doi: 10.1016/j.medmal.2008.09.002
  5. Cooper E.L., Kauschke E., Cossarizza A. Annelid humoral immunity: cell lysis in earthworms. Adv. Exp. Med. Biol., 2001, vol. 484, pp. 169–183.
  6. Farouk S.E., Mincheva-Nilsson L., Krensky A.M., Dieli F., Troye-Blomberg M. Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin. Eur. J. Immunol., 2004, vol. 34, no. 8, pp. 2248–2256.
  7. Good M.F. Towards a blood-stage vaccine for malaria: are we following all the leads? Nat. Rev. Immunol., 2001, vol. 1, no. 2, pp. 117–125.
  8. Impact — malaria. URL: http://en.sanofi.com/csr/patient/priorities/access_to_care/access_to_medicines/malaria/malaria.aspx (20.12.2014)
  9. Krishnegowda G., Hajjar A.M., Zhu J., Douglass E.J., Uematsu S., Akira S., Woods A.S., Gowda D.C. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J. Biol. Chem., 2005, vol. 280, no. 9, pp. 8606–8616.
  10. Lee K.S., Cox-Singh J., Brooke G., Matusop A., Singh B. Plasmodium knowlesi from archival blood films: Further evidence that human infections are widely distributed and not newly emergent in Malaysian Borneo. Int. J. Parasitol., 2009, vol. 39, no. 10, pp. 1125–1128, doi: 10.1016/j.ijpara.2009.03.003
  11. Makler M., Palmer C.J., Ager A.L. A review of practical techniques for the diagnosis of malaria. Ann. Trop. Med. Parsitol., 1998, vol. 92, no. 4, pp. 419–433.
  12. Malvry D., Djossou F., Thiebaut R., Le Bras M. Plasmodies-Malaria. Formes cliniques, diagnostic. In: Encycl. Méd. Chir., Maladies Infectieuses, 8-507-A-20, 2000, 16 p.
  13. Minodier P. Dépistage du paludisme: tests rapides. J. Pédiatr. Puéricuture. 2005, vol. 18, pp. 386–388.
  14. Pages F., Orlandi-Pradines E., Corbel V. Vecteurs du paludisme: biologie, diversité, contrôle et protection individuelle. Méd. Mal. Infect. 2007, vol. 37, no. 3, pp. 153–161.
  15. Pombo D.J., Lawrence G., Hirunpetcharat C., Rzepczyk C., Bryden M., Cloonan N., Anderson K., Mahakunkijcharoen Y., Martin L.B., Wilson D., Elliott S., Elliott S., Eisen D.P., Weinberg J.B., Saul A., Good M.F. Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. Lancet, 2002, vol. 360, no. 9333, pp. 610-617.
  16. Popov A.F., Lamah N.E., Konstantinov O.K., Baldé M.C., Camara S.K., Boiro M.Y. Manuel sur le paludisme. Conakry, 2007.
  17. Schofield L., Villaquiran J., Ferreira A., Schellekens H., Nussenzweig R., Nussenzweig V. Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature, 1987, vol. 330, no. 6149, pp. 664–666.
  18. Sergent E., Definition of immunity and premunition. Arch. Inst. Pasteur. Alger., 1950, vol. 28, no. 4, pp. 429–440.
  19. Siala E., Ben Abdallah R., Bouratbine A., Aoun K. Actualités du diagnostic biologique du paludisme: current biological diagnosis of malaria. Revue Tunisienne d’Infectiologie, 2010, vol. 4, pp. 5–9.
  20. Société de pathologie infectieuse de langue française (SPILF). Prise en charge et prévention du paludisme d’importation à Plasmodium falciparum recommandations pour la pratique clinique (Revision 2007 of the 1999 Consensus conference). Réanimation., 2008, vol. 17, pp. 1–54.
  21. World Health Orgnization. Severe falciparum malaria. Trans. R. Soc. Trop. Med. Hyg., 2000, vol. 94, suppl. 1, pp. 1–90.

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Copyright (c) 2016 Boiro M.Y., Boumbali S., Konstantinov O.K., Kalivogui S., Koulibali M., Bah A.S.

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