POPULATION IMMUNITY TO INFLUENZA VIRUS A(H1N1)pdm09, A(H3N2) AND B IN THE ADULT POPULATION OF THE RUSSIAN FEDERATION LONG-TERM RESEARCH RESULTS

Cover Page


Cite item

Full Text

Abstract

Analysis of changes in the population immunity level in adults for more than 20 Russian cities, collaborating with the Federal Center for Influenza, to circulating influenza viruses A(H1N1)pdm09, A(H3N2) and B in the period from 2009 to 2015 performed. By the beginning of the pandemic (October 2009) the population of Russia was almost seronegative to influenza A(H1N1)pdm09 virus. After the pandemia first wave mean geometric titers (GMT)s of antibodies to the pandemic virus increased by 2.6 times, after the second one by 4.9 times in comparison with initial GMT (1:5.5). A consistent increase in GMTs antibody after each of the subsequent seasons of active circulation of pandemic virus was observed reaching the maximum (1:41) by April 2013, after the next epidemic caused by this virus. The proportion of people with protective antibody titers in October 2009 to already started circulating influenza A(H1N1)pdm09 virus was 8.2%, to influenza A(H3N2) virus — 58.3%, and influenza B virus — 59.7%. Level of population immunity in adults to seasonal influenza A(H3N2) and B viruses throughout the observed period was significantly higher than to influenza virus A(H1N1)pdm09. The percentage of persons with protective antibody titers during the observed period varied for virus A(H3N2) in the range from 58.3 to 75.5%, for influenza B virus — from 59.7 to 82.3%. Accordingly, incidence rate for ILI and ARI in adult groups the population during influenza epidemic caused by these pathogens was lower than in the epidemics, associated with active circulation of influenza A(H1N1)pdm09 virus. The data obtained can be used in influenza forecasting for the upcoming season regarding the etiology and the expected epidemic intensity need for the relevant preventing measures development to decrease the burden from influenza.

About the authors

O. S. Konshina

Research Institute of Influenza Ministry of Health of the Russian Federation

Author for correspondence.
Email: olga.konshina@influenza.spb.ru

Researcher, Laboratory of Trials of Novel Remedies for Antiviral Protection

197376, Russian Federation, St. Petersburg, Prof. Popova str., 15/17, Phone: +7 921 920-18-11 (mobile)

Russian Federation

A. A. Sominina

Research Institute of Influenza Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Head of the Biotechnology Department, Head of the Laboratory of Biotechnology of Diagnostic Reagents

Russian Federation

E. A. Smorodintseva

Research Institute of Influenza Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD (Medicine), Leading Researcher, Laboratory of Biotechnology of Diagnostic Reagents

Russian Federation

K. A. Stolyarov

Research Institute of Influenza Ministry of Health of the Russian Federation

Email: fake@neicon.ru
Leading Software Developer, IT department Russian Federation

I. Yu. Nikonorov

Research Institute of Influenza Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD (Medicine), Leading Researcher, Laboratory of Trials of Novel Remedies for Antiviral Protection

Russian Federation

References

  1. Бюллетень Всемирной организации здравоохранения. 2012. Вып. 90. № 4. С. 245–320. [Bulletin of the World Health Organization, 2012, vol. 90, no. 4, pp. 245–320.]
  2. Грипп: эпидемиология, диагностика, лечение, профилактика. Под ред. О.И. Киселева, Л.М. Цыбаловой, В.И. Покровского. М.: Издательство «Медицинское информационное агентство», 2012. 496 с. [Gripp: epidemiologiya, diagnostika, lechenie, profilaktika. Pod red. O.I. Kiseleva, L.M. Tsybalovoi, V.I. Pokrovskogo [Influenza: epidemiology, diagnosis, treatment, prevention. Eds. Kiselev O.I., Tsybalova L.M., Pokrovsky V.I.]. Moscow: Publishing House “Meditsinskoe informa tsionnoe agentstvo”, 2012. 496 p.
  3. Карпова Л.С., Бурцева Е.И., Поповцева Н.М., Столярова Т.П. Сравнение эпидемий гриппа в России 2009 и 2011 годов, вызванных пандемическим вирусом гриппа A(H1N1) // Эпидемиология и вакцинопрофилактика. 2011. № 5 (60). С. 6–15. [Karpova L.S., Burtseva E.I., Popovtseva N.M., Stolyarova T.P. Comparison of influenza epidemics in Russia 2009 and 2011, caused by pandemic influenza A(H1N1). Epidemiologiya i vaktsinoprofilaktika = Epidemiology and Vaccinal Prevention, 2011, no. 5 (60), pp. 6–15 (In Russ.)]
  4. Карпова Л.С., Соминина А.А., Бурцева Е.И., Пелих М.Ю., Феодоритова Е.Л., Поповцева Н.М., Столярова Т.П., Киселев О.И. Сравнение эпидемий гриппа в России, вызванных пандемическим вирусом гриппа A(H1N1)pdm09, в период с 2009 по 2013 г. // Вопросы вирусологии. 2015. Т. 60, № 3. С. 19–24. [Karpova L.S., Sominina A.A., Burtseva E.I., Pelikh M.Yu., Feodoritova E.L., Popovtseva N.M., Stolyarova T.P., Kiselev O.I. Comparison of the influenza epidemics in Russia caused by the pandemic virus A(H1N1)pdm09 within the period from 2009 to 2013. Voprosy virusologii = Problems of Virology, 2015, vol. 60, iss. 3, pp. 19–24 (In Russ.)]
  5. Методы определения показателей качества иммунобиологических препаратов для профилактики и диагностики гриппа: Методические указания МУ 3.3.2.1758-03 (утв. Главным государственным санитарным врачом РФ 28 сентября 2003 г.) [Methods for determination of parameters of quality of immunobiological drugs for the prevention and diagnosis of influenza: Guidelines MU 3.3.2.1758-03 (app. Chief State Sanitary Doctor of the Russian Federation on September 28, 2003)]
  6. О совершенствовании системы эпидемиологического надзора и контроля за гриппом и острыми респираторными вирусными инфекциями: Приказ Роспотребнадзора от 31.03.2005 № 373. [On the improvement of system of influenza surveillance and control, and acute respiratory viral infections: Rospotrebnadzor Order 31.03.2005 No. 373.]
  7. Смородинцев А.А. Грипп и его профилактика: руководство для врачей. Л.: Медицина, 1984. C. 164–196. [Smorodintsev A.A. Gripp i ego profilaktika: rukovodstvo dlya vrachei [Influenza and its prevention: a guide for physicians]. Leningrad: Medicina, 1984, pp. 164–196.]
  8. Ambrose C.S., Levin M.J. The rationale for quadrivalent influenza vaccines. Hum. Vaccin. Immunother., 2012, vol. 8, pp. 81–88. doi: 10.4161/hv.8.1.17623
  9. Metcalf C.J.E., Ferrari M., Graham A.L., Grenfell B.T. Understanding herd immunity. Trends Immunol., 2015, vol. 36, no. 12, pp. 753–755. doi: 10.1016/j.it.2015.10.004
  10. Sominina A., Burtseva E., Eropkin M., Karpova L., Zarubaev V., Smorodintseva E., Konovalova N., Danilenko D., Prokopetz A., Grudinin M., Pisareva M., Anfimov P., Stolyarov K., Kiselev O., Shevchenko E., Ivanova V., Trushakova S., Breslav N., Lvov D., Klimov A., Moen A., Cox N. Influenza surveillance in Russia based on epidemiological and laboratory data for the period from 2005 to 2012. Am. J. Infect. Dis., 2013, vol. 9, no. 3, pp. 77–93. doi: 10.3844/ajidsp.2013.77.93

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Konshina O.S., Sominina A.A., Smorodintseva E.A., Stolyarov K.A., Nikonorov I.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies