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Инфекция и иммунитет

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ИСПОЛЬЗОВАНИЕ МЫШИНОЙ МОДЕЛИ ДЛЯ АНАЛИЗА ИММУННОГО ОТВЕТА К ИНФЕКЦИЯМ МЕТОДАМИ КЛАССИЧЕСКОЙ ГЕНЕТИКИ

https://doi.org/10.15789/2220-7619-2011-4-293-302

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Аннотация

Резюме. Установление и изучение многочисленных функций всех генов человека является одной из главных задач современной биологической науки. Вследствие высокой степени гомологии между мышиным и человеческим геномами, важная роль в решении этой задачи принадлежит мышиной модели, использование которой в классической генетике особенно возросло в связи с выведением различных инбредных мышиных линий. Так, например, различия в иммунном ответе к инфекциям в разных мышиных линиях были неоднократно использованы для нахождения иммунологически компетентных генов. Именно поэтому трудно переоценить вклад мышиной модели в понимание механизмов иммунного ответа к инфекциям. В данном обзоре приведены некоторые из наиболее успешных и известных примеров использования мышей в изучении противоинфекционного ответа.

Об авторе

А. Полторак
Tufts University, Бостон
Соединённые Штаты Америки


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Для цитирования:


Полторак А. ИСПОЛЬЗОВАНИЕ МЫШИНОЙ МОДЕЛИ ДЛЯ АНАЛИЗА ИММУННОГО ОТВЕТА К ИНФЕКЦИЯМ МЕТОДАМИ КЛАССИЧЕСКОЙ ГЕНЕТИКИ. Инфекция и иммунитет. 2011;1(4):293-302. https://doi.org/10.15789/2220-7619-2011-4-293-302

For citation:


Poltorak A. USING OF MOUSE MODEL TO ANALYZE IMMUNE RESPONSE TO INFECTIOUS PATHOGENS BY THE METHODS OF CLASSICAL GENETICS. Russian Journal of Infection and Immunity. 2011;1(4):293-302. (In Russ.) https://doi.org/10.15789/2220-7619-2011-4-293-302

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