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МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСНОВЫ ФИЗИОЛОГИИ И ПАТОГЕННОСТИ COXIELLA BURNETII

https://doi.org/10.15789/2220-7619-2012-3-615-626

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Аннотация

Резюме. Возбудитель Ку-лихорадки, Coxiella burnetii, является достаточно необычным внутриклеточным патогеном, обладающим значительно большими транспортными и метаболическими способностями, нежели микроорганизмы со сходной паразитической стратегией. Предполагается, что разные штаммы патогена находятся на разных стадиях процесса патоадаптации и обладают различным вирулентным потенциалом. В обзоре рассматривается структура генома C. burnetii, особенности метаболических путей, механизмы взаимодействия с клеткой хозяина и возможные факторы вирулентности. Особое внимание уделяется методам генотипирования коксиелл и возможной корреляции между геномным полиморфизмом различных штаммов и их вирулентным потенциалом.

Об авторе

Ю. А. Панферова
ФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург
Россия

научный сотрудник лаборатории зооантропонозов

197101, Санкт-Петербург, ул. Мира, 14



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Для цитирования:


Панферова Ю.А. МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСНОВЫ ФИЗИОЛОГИИ И ПАТОГЕННОСТИ COXIELLA BURNETII. Инфекция и иммунитет. 2012;2(3):615-626. https://doi.org/10.15789/2220-7619-2012-3-615-626

For citation:


Panpherova Y.A. MOLECULAR-GENETIC BASIS OF PHYSIOLOGY AND PATHOGENICITY OF COXIELLA BURNETII. Russian Journal of Infection and Immunity. 2012;2(3):615-626. (In Russ.) https://doi.org/10.15789/2220-7619-2012-3-615-626

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